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Table 2 Anthropometric Measures (Body Mass Index; Weight; Height; Waist Circumference; Overall and Abdominal Obesity; Percentage Body Fat), Fasting Insulin and Glucose, Post-Oral Glucose Tolerance Test Response, and Diabetic Control Characteristics Weighted Means (Standard Deviations) or Frequencies across rs7903146 Genotypes (n = 9031) at the Hispanic Community Health Study/Study of Latinos Baseline Examination

From: Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

 

CC

CT

TT

P-value

Unweighted total analytic sample size

n = 5040

n = 3373

n = 618

 

Measured BMIa (kg/m2)

29.74 (0.17)

29.26 (0.13)

29.21 (0.28)

0.06

Self-Reported BMIa (kg/m2)

29.81 (0.17)

29.34 (0.13)

29.23 (0.27)

0.05

Measured Weight (kg)

80.09 (0.52)

78.71 (0.39)

78.58 (0.79)

0.1

Self-Reported Weight (kg)

80.29 (0.53)

78.94 (0.39)

78.69 (0.76)

0.1

Measured Height (cm)

163.93 (0.18)

163.83 (0.19)

163.94 (0.32)

0.9

% Overall Measured Obesity (≥30 kg/m2 Measured BMI)

42.43%

37.89%

38.55%

0.03

% Overall Self-Reported Obesity (≥30 kg/m2 Self-Reported BMI)

43.29%

38.85%

37.66%

0.03

Waist Circumference (cm)

98.41 (0.40)

97.37 (0.31)

97.34 (0.65)

0.09

% Abdominal Measured Obesity (≥120 cm for men; ≥88 cm for women)

56.1%

55.2%

57.1%

0.7

% Body Fat

33.58 (0.21)

32.96 (0.19)

33.18 (0.4)

0.08

% Identified as Diabetic Before or at Baseline Examinationb

14.77%

18.24%

21.01%

0.0002

Unweighted non-diabetic subsample

n = 4107

n = 2586

n = 454

 

Fasting Insulin (mU/L)

11.98 (0.2)

11.96 (0.19)

11.53 (0.47)

0.7

Fasting Glucose (mg/dL)

93.78 (0.18)

94.12 (0.23)

94.67 (0.51)

0.2

HOMA Index of Beta Cell Function

145.17 (2.59)

140.81 (2.33)

133.28 (4.81)

0.07

HOMA Index of Insulin Resistance

2.82 (0.05)

2.84 (0.05)

2.75 (0.12)

0.8

post OGTT Insulin (mU/L)c

78.06 (1.81)

81.09 (1.84)

75.39 (3.2)

0.2

post OGTT, Glucose (mg/dL)c

112.25 (0.78)

114.23 (0.85)

115.85 (1.6)

0.06

Glycated Hemoglobin (mmol/mol)

35.77 (0.1)

35.99 (0.1)

35.72 (0.22)

0.2

% Glycated Hemoglobin

5.42 (0.01)

5.44 (0.01)

5.41 (0.02)

0.2

Unweighted diabetic b subsample

n = 933

n = 787

n = 164

 

Glycated Hemoglobin (mmol/mol)

57.55 (1.25)

57.79 (0.94)

60.06 (2.06)

0.6

% Glycated Hemoglobin

7.42 (0.11)

7.44 (0.09)

7.64 (0.19)

0.6

% Controlled Diabetes (< 7% Glycated Hemoglobin)

26.1%

31.2%

35.3%

0.1

  1. All weighted means and standard deviations (or percentages) for anthropometric measures (weight, height, body mass index, waist circumference, fat percentage, overall and abdominal obesity) were estimated from regression models, which accounted for the complex sampling design and age, sex, and ancestry proportions. Additionally, all other weighted means and standard deviations (or percentages) were adjusted for body mass index (BMI) at examination. rs7903146 genotypes were modeled dis-jointly (i.e. no additive model was assumed)
  2. aMeasured and self-reported BMI values at baseline were based off of measured weight and height, and self-reported weight and measured height, respectively
  3. bThe diabetes subsample included individuals reporting having received a previous diabetes diagnosis at baseline examination, or being identified as diabetic at the baseline examination
  4. c2-h Oral Glucose Tolerance Test (OGTT) was conducted in only individuals who did not report having had a previous diabetes diagnosis
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BMC Obesity

ISSN: 2052-9538

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